73: Increased kernicterus rate in homozygous Gunn rats after application of different antibiotics

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چکیده

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Correction of congenital hyperbilirubinemia in homozygous Gunn rats by xenotransplantation of hamster livers.

The homozygous Gunn(j/j) rat is an animal model for Crigler-Najjarsyndrome in which the lack of the enzyme uridine diphosphoglucoronate-glucuronosyltransferase (UDP-GT) results in congenital unconjugated nonhemolytic hyperbilirubinemia. Because the binding of bilirubin to albumin in plasma varies from species to species, xenotransplantation (XTx) of liver afforded in this model the opportunity ...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1976

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-197610000-00067